Combined effects of chronic ionizing radiation and repeated laser exposure on cognitive functions of rats

Low-level laser therapy (LLLT) may have utility in the management of side effects radiation head and neck cancer (HNC) patients. Although evidence suggests that LLLT is safe treatment for HNC patients, more research imperative vigilance remains warranted to de-tect any potential adverse on outcomes survival The purpose this study was evaluate effect transcranial low-level irradiation (LLLI) combined with whole-body ionizing (IR) conditioned-reflex activity rats. Seventy healthy Wistar female rats were distributed into following groups: Group 1, sham control; 2, LLLI; 3, IR; 4, IR LLLI. 3 4 chronically ex-posed (30 days; 5,3+/-0,5 mGy/h; 3,7 Gy). 2 received five applications LLLI, once a day 15 min (wavelength 890 nm, pulse duration 100 ns, impulse fre-quency 10000 Hz, output power – 1,7 mW). Cognitive functions tested using shut-tle-box avoidance method. 30 minutes later, 24 hours 14 days af-ter end LLLI isolated action (groups 3) did not significantly affect conditioned reflex negative exposure these factors (group 4) development reproduction an active within revealed. Gradually weakened two weeks leveled. Thus, pose danger cognitive function brain.